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  • P-ISSN1225-0163
  • E-ISSN2288-8985
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  • P-ISSN 1225-0163
  • E-ISSN 2288-8985

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LC/ESI-MS/MS를 이용한 하천수 중 잔류 6종 의약물질의 동시분석 및 모니터링

Simultaneous analysis and occurrences of six pharmaceuticals in surface water by LC/ESI-MS/MS

분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2010, v.23 no.6, pp.572-578
https://doi.org/10.5806/AST.2010.23.6.572
김병주 (경기대학교)
명승운 (경기대학교)
김병주, & 명승운. (2010). LC/ESI-MS/MS를 이용한 하천수 중 잔류 6종 의약물질의 동시분석 및 모니터링. , 23(6), 572-578, https://doi.org/10.5806/AST.2010.23.6.572

초록

본 연구에서는 하천수 중 6종의 의약물질(cephradine, cefadroxil, penicillin G, vancomycin, iopromide, and fenbendazole)에 대한 전처리법과 분석 방법을 확립하였다. 하천수 중의 분석물질을 HLB(Hydrophilic-Lipophilic Balanced) 카트리지를 사용하여 추출/정제 및 농축하였다. HPLC/ESI-MS/MS를 이용하여 6종의 물질들을 동시에 분석하였다. Fenbendazole을 제외한 의약물질은 71.1~92.6% 범위의 양호한 회수율을 나타내었고, 상대표준편차는 11.2% 이하로 나타났다. 정량분석을 위해서 0.007~1.2 ng/mL 범위에서 $r^2$

keywords
pharmaceuticals, surface water, chemical analysis, LC/ESI-MS/MS

Abstract

In this study, sample preparation and analytical method for the monitoring of six pharmaceuticals (cephradine, cefadroxil, penicillin G, vancomycin, iopromide, and fenbendazole) in surface water was investigated. The extraction/clean-up and concentrating of pharmaceuticals from surface water were performed by HLB (Hydrophilic-Lipophilic Balanced) cartridge. The method allows for the simultaneous determination of six pharmaceuticals by HPLC/ESI(+)-MS/MS. Recoveries of the pharmaceutical were between 71.1 to 92.6%(except fenbendazole) and the overall variability of the method was below 11.2% (RSD). The calibration curves for the pharmaceuticals from blank surface water showed good linearities (above r2 = 0.99) in the concentration range of 0.007~1.2 ng/mL. The limit of detection (LOD) and the limit of quantification (LOQ) were 7.2~128.7pg/mL and 23.8~429.1 pg/mL, respectively. The present analytical method can be useful for monitoring residual pharmaceuticals in surface water and other aquatic samples. High concentrations of iopromide and fenbendazole were detected in a few samples of surface water.

keywords
pharmaceuticals, surface water, chemical analysis, LC/ESI-MS/MS

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