- P-ISSN 2233-4203
- E-ISSN 2093-8950
- P-ISSN2233-4203
- E-ISSN2093-8950
- ESCI, SCOPUS, KCI
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Evaluation of the inhibitory effect of Gynostemma pentaphyllum extracts on CYP450 enzyme activities using LC-MS/MS
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2023, v.14 no.3, pp.116-119
https://doi.org/10.5478/MSL.2023.14.3.116
(Hanyang University)
(Hanyang University)
(Hanyang University)
(Minzu University of China)
(Hanyang University)
(Hanyang University)
(Hanyang University)
(Minzu University of China)
(Hanyang University)
Yu,
J. S., Ji,
Y. S., Jo,
S. Y., Piao,
X., &
Yoo,
H.
H.
(2023). . , 14(3), 116-119, https://doi.org/10.5478/MSL.2023.14.3.116
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Abstract
Gynostemma pentaphyllum (Thunb.) Makino extract, a natural product with a history of traditional use, has gained attention for its potential health benefits. This study aimed to investigate its effects on key cytochrome P450 (CYP) enzymes using LC-MS/MS. Human liver microsomes and cDNA-expressed CYP2C8, CYP2C9, CYP2C19, and CYP3A4 supersomes were employed. Enzyme activity was assessed based on the formation of CYP-specific marker metabolites. The resulting data showed that the extract exhibited inhibitory effects on CYP2C8, CYP2C9, CYP2C19, and CYP3A4. Thus, G. pentaphyllum extract may influence the pharmacokinetics of drugs metabolized by CYP2C8, CYP2C9, CYP2C19, and CYP3A4. These find- ings emphasize the importance of considering potential herb-drug interactions when incorporating this extract into therapeutic regimens or dietary supplements.
- keywords
- Gynostemma pentaphyllum, cytochrome P450, herb-drug interaction, LC-MS/MS
- 투고일Received
- 2023-09-28
- 수정일Revised
- 2023-09-29
- 게재확정일Accepted
- 2023-09-28
- 출판일Published
- 2023-09-30
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