Separation of racemin enantiomer carvedilol and its metabolites using capillary electrophoresis

명승운; 조천호; 구소현

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P-ISSN1225-0163
E-ISSN2288-8985
SCOPUS, ESCI, KCI

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P-ISSN 1225-0163
E-ISSN 2288-8985

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19권 4호

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Capillary Electrophoresis에 의한 Carvedilol 및 그 대사체의 거울상이성질체 분리

Separation of racemin enantiomer carvedilol and its metabolites using capillary electrophoresis

분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985

2006, v.19 no.4, pp.275-279

명승운 (경기대학교 이과대학 화학과)
조천호
구소현

명승운, 조천호, & 구소현. (2006). Capillary Electrophoresis에 의한 Carvedilol 및 그 대사체의 거울상이성질체 분리. , 19(4), 275-279.

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Abstract

A capillary electrophoresis method for the separation of carvedilol and its metabolites enantiomers using cyclodextrins as the chiral selectors was developed. The effect of several types of cyclodextrins, concentration and capillary temperature for enantiomer resolution were investigated. Best results were obtained by 15 mM carboxymethyl-${\beta}$-cyclodextrin in the run buffer. Also the effect of capillary temperature on efficiency was assessed. The optimized method was applied for separation of chiral carvedilol and its three metabolites.

keywords: carvedilol, metabolite, enantiomer, capillary electrophoresis, separation

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Capillary Electrophoresis에 의한 Carvedilol 및 그 대사체의 거울상이성질체 분리

Separation of racemin enantiomer carvedilol and its metabolites using capillary electrophoresis

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