Study on the confirmation of drinking at the bloods & urines used 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol

김명덕; 김영운; 권오성; 박세연; 김은호

오늘 하루 그만보기

P-ISSN1225-0163
E-ISSN2288-8985
SCOPUS, ESCI, KCI

Home

Browse Articles

Article Detail

Home > Article Detail

P-ISSN 1225-0163
E-ISSN 2288-8985

e-Submission

Vol.20, No.3

PubReader PDF Citation

Study on the confirmation of drinking at the bloods & urines used 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol

Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985

2007, v.20 no.3, pp.204-212

& (2007). Study on the confirmation of drinking at the bloods & urines used 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol. , 20(3), 204-212.

copy

Abstract

The study was carried out to investigate the ratio of ethanol to n-propanol in blood and urine specimens, and developed a method for distinguishing ingested ethanol from artifactual ethanol in urine samples. In case of no urinary ethanol was detected, the ratio of ethanol to n-propanol concentration was about 12~20 times higher than those of blood. Therefore, it might be a good method to determine whether the detected ethanol is from drinking or from microbial fermentation. During the metabolism of ethanol, the levels of the metabolite of serotonin (5-hydroxytryptamine, 5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) were decreased, while 5-hydroxytryptophol (5-HTOL) was increased. The levels of 5-HTOL/5-HIAA in urine samples of drinking suspects were greater than 1, in that of no drinking suspects were less than 1.