- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
Home > Article Detail
Chip-based isothermal amplification method for EGFR gene mutations in lung cancer
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2009, v.22 no.6, pp.498-503
&
(2009). Chip-based isothermal amplification method for EGFR gene mutations in lung cancer. , 22(6), 498-503.
Abstract
Lung cancer is the main cancer on the world today, due to the high case fatality. Lung cancer can devide into two major types, such as small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Mutations in the epidermal growth factor receptor (EGFR) have been described in patients with advanced NSCLC. Mutations in the EGFR are associated with clinical and radiographic responses to EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Thus, the detection of EGFR mutation can offer an effective information in clinical decision-making. In this study, We developed very simple, cheep and rapid mutation detection system by chip-based isothermal amplification method. The method described here has shown the advantages of rapid amplification, high sensitivity, and specificity. Also, it will be useful for rapid and reliable clinical diagnosis of EGFR mutation.
- keywords
- Chip, EGFR (Epidermal Growth Factor Receptor), Isothermal Amplification, Non-Small-Cell Lung Cancer (NSCLC)
Other articles from this issue
- Development of the testing method for newly regulated hazardous compounds in electrical and electronic equipments
- Analysis and exposure assessment of the total PCBs in foods
- Determination of residual flumethrin in honey products by HPLC
- Oxidation behavior on the surface of titanium metal specimens at high temperatures (300~1000℃)
- Analytical method of PCBs-containing solid wastes
- The measurement of dicamba in soil and plants
- A study on the calibration characteristics of organic fatty acids designated as new offensive odorants by cryogenic trapping-thermal desorption technique
- Chip-based isothermal amplification method for EGFR gene mutations in lung cancer
- Distribution of hazardous heavy metals in commercial herbal medicines classified by plant parts used in seoul
- Analysis of coenzyme Q10 in human plasma by high performance liquid chromatography
- Removal of I⁻ and IO₃⁻ from Aqueous Solution
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.