Measurement of optical purity for commercial naproxen by chiral HPLC

유정재; 류재정; 이원두

doi:10.5806/AST.2011.24.5.360

오늘 하루 그만보기

P-ISSN1225-0163
E-ISSN2288-8985
SCOPUS, ESCI, KCI

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P-ISSN 1225-0163
E-ISSN 2288-8985

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Vol.24, No.5

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Measurement of optical purity for commercial naproxen by chiral HPLC

Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985

2011, v.24 no.5, pp.360-367

https://doi.org/10.5806/AST.2011.24.5.360

& (2011). Measurement of optical purity for commercial naproxen by chiral HPLC. , 24(5), 360-367, https://doi.org/10.5806/AST.2011.24.5.360

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Abstract

Optical purities of 10 commercialized naproxens prepared from eight Korean drug companies were examined by an optimized chiral HPLC condition. The Chiralcel OD-H column and ChiralHyun-LE(S)-1 column were used as chiral stationary phases and the mixed eluent of hexane/isopropanol/acetic acid as 100:2.85:0.1was used as a mobile phase for effective enantioseparation. Optical purity values of most samples were higher than 97 percents, only one of them was about 95 percents. The average relative standard deviation of them appeared very small (0.034%).