- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
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An Analysis of the proteomics approach to the glycated peptides of human milk
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2022, v.35 no.1, pp.8-14
https://doi.org/10.5806/ast.2022.35.1.8
(College of Pharmacy, Gachon University)
(College of Pharmacy, Gachon University)
(College of Pharmacy, Gachon University)
(Department of Pediatrics, Soonchunhyang University)
(Department of Nursing, Konkuk University)
(College of Pharmacy, Gachon University)
(College of Pharmacy, Gachon University)
(Department of Pediatrics, Soonchunhyang University)
(Department of Nursing, Konkuk University)
Cho,
S., Park,
J., Lee,
H., Song,
J. H., &
Kang,
N.
M.
(2022). An Analysis of the proteomics approach to the glycated peptides of human milk, 35(1), 8-14, https://doi.org/10.5806/ast.2022.35.1.8
Abstract
Many studies have shown that advanced glycation end-products (AGEs) and glycation adducts are significantly linked to aging and disease. Particularly, the level of glycation in human milk is important because the AGE intake is closely related to AGE levels in infants. In this study, we used human milk samples obtained from four primiparae and four multiparae. We isolated proteins using acetone and trichloroacetic acid (TCA) precipitation. A total of 67 glycated proteins and 122 glycated peptides was quantified; among them, 19 glycated peptides were differentially expressed. We confirmed that the degree of glycation differed according to fertility. The study provides a foundation for using proteomics to evaluate the mother's milk quality and link between maternal health and human milk quality.
- keywords
- glycation, advanced glycation end-product, human milk, LC-MS/MS, fertility
Graphical Abstract
- Received
- 2021-10-25
- Revised
- 2021-12-30
- Accepted
- 2022-01-13
- Published
- 2022-02-25
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