A Review: Synthesis and characterization of metals complexes with paracetamol drug

AL-Ayash Salam R; AL-AyashSalamR; AL-Noor Taghreed H; AL-NoorTaghreedH

doi:10.5806/ast.2022.35.4.143

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P-ISSN1225-0163
E-ISSN2288-8985
SCOPUS, ESCI, KCI

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P-ISSN 1225-0163
E-ISSN 2288-8985

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Vol.35, No.4

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A Review: Synthesis and characterization of metals complexes with paracetamol drug

Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985

2022, v.35 no.4, pp.143-152

https://doi.org/10.5806/ast.2022.35.4.143

Salam R AL-Ayash (Chemistry Department, College of Education for Pure Science Ibn-Al-Haithem, University of Baghdad)
Taghreed H AL-Noor (Chemistry Department, College of Education for Pure Science Ibn-Al-Haithem, University of Baghdad)

AL-Ayash, S. R., & AL-Noor, T. H. (2022). A Review: Synthesis and characterization of metals complexes with paracetamol drug, 35(4), 143-152, https://doi.org/10.5806/ast.2022.35.4.143

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Abstract

In this review, previous studies on the synthesis and characterization of the metal Complexes with paracetamol by elemental analysis, thermal analysis, (IR, NMR and UV-Vis (spectroscopy and conductivity. In reviewing these studies, the authors found that paracetamol can be coordinated through the pair of electrons on the hydroxyl O-atom, carbonyl O-atom, and N-atom of the amide group. If the paracetamol was a monodentate ligand, it will be coordinated by one of the following atoms O-hydroxyl, O-carbonyl or N-amide. But if the paracetamol was bidentate, it is coordinated by atoms (O-carbonyl and N-amide), (O-hydroxyl and N-amide) or (O-carbonyl and O-hydroxyl). The authors also found that free paracetamol and its complexes have antimicrobial activity.