- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
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Effect of deep eutectic solvent (DES) on the extraction of asiaticoside and madecassoside from Centella asiatica
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2023, v.36 no.3, pp.128-134
https://doi.org/10.5806/ast.2023.36.3.128
(Department of Chemistry, Hannam University)
(Department of Chemical Engineering, Hannam University)
(Department of Chemical Engineering, Hannam University)
(Department of Chemical Engineering, Hannam University)
(Department of Chemical Engineering, Hannam University)
Choi,
J., Jeon,
Y., &
Ha,
S.
H.
(2023). Effect of deep eutectic solvent (DES) on the extraction of asiaticoside and madecassoside from Centella asiatica, 36(3), 128-134, https://doi.org/10.5806/ast.2023.36.3.128
Abstract
Centella asiatica (C. asiatica) extracts, including asiaticoside and madecassoside, are used in ointments to treat the wound and atopic dermatitis due to their antibacterial and skin-regenerating effects in Asia. Therefore, research on the cultivation and extraction efficiency of C. asiatica is being actively conducted to increase commercialization efficiency. In this study, various deep eutectic solvents (DESs) were prepared and used as the extraction solvents according to the mole ratio between the hydrogen bond acceptor (HBA) and hydrogen bond donor (HBD). And then, the extraction yields in distilled water (DW) and methanol (MeOH), commonly used extraction solvents for C. asiatica, were compared and analyzed by HPLC in the optimized operating condition. As a result, a mixture of DW and DES at a ratio of 3:7 showed about 1.4 times higher extraction efficiency than MeOH only. Conversely, the extraction efficiency in a mixture of MeOH and DES at a ratio of 3:7 was about 6 % lower than that in MeOH only.
- keywords
- Centella asiatica, Asiaticoside, Madecassoside, Quantitative analysis, Deep eutectic solvent (DES), Extraction, HPLC
Graphical Abstract
- Received
- 2023-02-27
- Revised
- 2023-03-15
- Accepted
- 2023-03-16
- Published
- 2023-06-25
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