- P-ISSN1738-6764
- E-ISSN2093-7504
- KCI
ISSN : 1738-6764
Protective effect of Tranilast on radiation-induced heart fibrosis in C57BL/6 mouse
INTERNATIONAL JOURNAL OF CONTENTS / INTERNATIONAL JOURNAL OF CONTENTS, (P)1738-6764; (E)2093-7504
2012, v.8 no.4, pp.64-69
https://doi.org/10.5392/ijoc.2012.8.4.064
Moon, Seongkwon
(Radiation Oncology, College of Medicine, Soonchunhyang University Bucheon Hospital)
Moon, Seongkwon.
(2012). Protective effect of Tranilast on radiation-induced heart fibrosis in C57BL/6 mouse. , 8(4), 64-69, https://doi.org/10.5392/ijoc.2012.8.4.064
Abstract
The heart is a major dose-limiting organ for radiotherapy of cancer in the thoracic region. The purpose of this study was to examine the protective effect of tranilast on the radiation-induced heart fibrosis model using the C57BL/6 murine strain. A significant reduction in the expression of TGF-<TEX>${\beta}1$</TEX>, collagen type I and collagen type III was observed in the radiation plus tranilast group. The authors also suggest the use of tranilast in a clinical trial for the prevention of radiation-induced heart fibrosis.
- keywords
- Heart Fibrosis, Radiation, Tranilast
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