Abstract

Objectives: Leukocyte platelet-rich fibrin (L-PRF) has garnered attention due to its biocompatibility, low cost, and regenerative potential. This paper presents a clinical case series demonstrating the versatility and effectiveness of L-PRF in oral and maxillofacial surgery. Patients and Methods: This case series comprised six patients who underwent comprehensive clinical and imaging evaluations and were recommended for oral surgery interventions using L-PRF. The cases include venipuncture, L-PRF preparation, and its clinical applications. Results: In Patient 1, an oroantral communication was closed using an L‑PRF membrane and vestibular flap, achieving satisfactory soft‑tissue healing. Patient 2 underwent a maxillary sinus lift with bone graft material and L‑PRF membranes (replacing collagen membranes) to reduce cost and enhance bone regeneration. In Patients 3 to 5 (all systemically compromised), post‑extraction placement of an L‑PRF plug and membranes prevented complications and preserved the alveolar ridge for future rehabilitation. Finally, Patients 6 and 7, both with recurrent pericoronitis of partially erupted lower third molars, received extractions followed by L‑PRF plug and membrane placement, with uneventful healing in all cases. The findings reinforce the growing body of evidence supporting the benefits of L-PRF in oral and maxillofacial surgery. Conclusion: L-PRF represents a promising, biocompatible tool in clinical practice, offering significant advantages for patient recovery and surgical outcomes.