Journal of the Korean Association of Oral and Maxillofacial Surgeons

초록

본 교실에서는, 경구개에 발생한 과립세포종을 경험하여 문헌 고찰과 함께 면역조직화학적 특성을 확인 하여 기술 하였다. 본 종양세포는 S-100, CD68, NSE 등에 양성 반응을 보여, 과립세포종의 기원이 neural origin, 특히 Shwann’s cell이라는 최근의 여러 연구들의 결론에 병행함을 보였다. 증례가 많지 않은 본 종양에 대한 향후 더 많은 증례와 연구가 필요하리라 사료된다.

Abstract

Granular cell tumor is a uncommon disease, although head and neck region accounts for approximately 50% of all lesions, 70% are located in oral cavity but can occur at other site of the body. Clinically, it usually presents as a small, slow growing, non-tender, single benign lesion but mutifocal and malignant forms are rarely encountered. The histogenic origin of this tumor was controversial for many years but recent studies using immunohistochemical study support its origin being from neural cell, probably Schwann’s cell. In this report, we present a case of benign granular cell tumor occurred on the hard palate studied by histologic and immunohistochemical assay, with review of literatures.