Development and validation of a portable gas chromatograph method for  quantitative determination of oxygen and toxic gas impurities in medical oxygen using planar microchromatographic columns and detectors

EkaterinaV.Galeeva Ekaterina V. Galeeva; EkaterinaV.Galeeva; Roman R. Galeev Roman R. Galeev; RomanR.Galeev; Prachi Sharma Prachi Sharma; PrachiSharma; Alexander l. Khokhlov Alexander l. Khokhlov; Alexanderl.Khokhlov; Dmitry V. Somov Dmitry V. Somov; DmitryV.Somov; Dmitry A. Semanov Dmitry A. Semanov; DmitryA.Semanov; Ilshat R. Aryslanov Ilshat R. Aryslanov; IlshatR.Aryslanov; Natalia А. Lezhnina Natalia А. Lezhnina; NataliaА.Lezhnina; Vladimir Platonov Vladimir Platonov; VladimirPlatonov; Nishant Tripathi Nishant Tripathi; NishantTripathi

doi:10.5806/ast.2024.37.5.261

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P-ISSN1225-0163
E-ISSN2288-8985
SCOPUS, ESCI, KCI

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P-ISSN 1225-0163
E-ISSN 2288-8985

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Vol.37, No.5

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Development and validation of a portable gas chromatograph method for quantitative determination of oxygen and toxic gas impurities in medical oxygen using planar microchromatographic columns and detectors

Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985

2024, v.37 no.5, pp.261-270

https://doi.org/10.5806/ast.2024.37.5.261

EkaterinaV.Galeeva Ekaterina V. Galeeva (Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of Roszdravnadzor, Yaroslavl State Medical University)
Roman R. Galeev Roman R. Galeev (Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of Roszdravnadzor, Kazan Federal University, Yaroslavl State Medical University)
Prachi Sharma Prachi Sharma (School of Electronics Engineering (SENSE), Vellore Institute of Technology (VIT), Samara National Research University)
Alexander l. Khokhlov Alexander l. Khokhlov (Yaroslavl State Medical University)
Dmitry V. Somov Dmitry V. Somov (Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of Roszdravnadzor)
Dmitry A. Semanov Dmitry A. Semanov (Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of Roszdravnadzor, Kazan Federal University)
Ilshat R. Aryslanov Ilshat R. Aryslanov (Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of Roszdravnadzor)
Natalia А. Lezhnina Natalia А. Lezhnina (Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of Roszdravnadzor, Yaroslavl State Medical University)
Vladimir Platonov Vladimir Platonov (Samara National Research University)
Nishant Tripathi Nishant Tripathi (Samara National Research University)

EkaterinaV.Galeeva, E. V. G., Roman R. Galeev, R. R. G., Prachi Sharma, P. S., Alexander l. Khokhlov, A. l. K., Dmitry V. Somov, D. V. S., Dmitry A. Semanov, D. A. S., Ilshat R. Aryslanov, I. R. A., Natalia А. Lezhnina, N. А. L., Vladimir Platonov, V. P., & Nishant Tripathi, N. T. (2024). Development and validation of a portable gas chromatograph method for quantitative determination of oxygen and toxic gas impurities in medical oxygen using planar microchromatographic columns and detectors. , 37(5), 261-270, https://doi.org/10.5806/ast.2024.37.5.261

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Abstract

This study examines portable Gas Chromatography (GC) for the quantitative analysis of oxygen and impurities, focusing on the development and validation of a method to determine oxygen, carbon monoxide, carbon dioxide, methane, and nitrogen in medical compressed oxygen gas. The goal is to ensure the quality of medicalgrade oxygen. The method's validation assessed its metrological characteristics, demonstrating specificity through clear chromatographic separation of the target gases and the absence of these peaks in the carrier gas chromatogram. It exhibited linearity within the designated concentration ranges, while precision met permissible standards, with the relative standard deviation for intermediate precision being less than 4% for carbon monoxide (0.00025 - 0.00099 %), less than 3 % for methane (0.0005 - 0.00246%) and carbon dioxide (0.0050 - 0.0150 %), less than 2% for nitrogen (0.1 - 0.7 %), and less than 0.01% for oxygen (99.27 - 99.98%). Overall, the validation results confirm the suitability of this analytical method for the quantitative determination of the aforementioned gases in medical compressed oxygen using portable GC with microchromatographic columns and detectors.