Determination of 2-Mercapto-1-methyl-imidazole in Antithyroid Drug by Differential Pulse Polarography

Kim, Il Kwang; 김일광; Chun, Hyun Ja; 천현자; Lim, Soon Hwa; 임순화

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P-ISSN1225-0163
E-ISSN2288-8985
SCOPUS, ESCI, KCI

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P-ISSN 1225-0163
E-ISSN 2288-8985

e-Submission

Vol.8, No.1

PubReader Citation

Determination of 2-Mercapto-1-methyl-imidazole in Antithyroid Drug by Differential Pulse Polarography

Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985

1995, v.8 no.1, pp.17-23

Kim, Il Kwang
Chun, Hyun Ja
Lim, Soon Hwa

Kim, I. K., Chun, H. J., & Lim, S. H. (1995). Determination of 2-Mercapto-1-methyl-imidazole in Antithyroid Drug by Differential Pulse Polarography. , 8(1), 17-23.

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Abstract

The determination method of 2-mercapto-1-methyl-imidazole(MMI) in $5.0{\times}10^{-2}M$ lithium perchlorate solution has been investigated by the differential pulse polarography. The optimum conditions for the determination of MMI were as fellows; -0.9 volt(vs. Ag/AgCl) initial potential, 80mV pulse height, 2mV/sec scan rate, and medium mercury drop size. The calibration curve showed a good linearlity in the range of $1.0{\times}10^{-7}M$ to $8.0{\times}10^{-5}M$ and the detection limit was $2.2{\times}10^{-9}M$. This method was applicable to the determination of MMI in thyroid drugs without interference from the additives.