- ENGLISH
- P-ISSN3022-6805
- E-ISSN3022-6791
- KCI
Neuroprotective Effects of Nebbiolo Red Wine Against Ethanol-induced Cognitive Dysfunction and Neurotoxicity
Seong-Hoon Yun (JBK-LAB, Inc.)
Hye-Yeon Kang (JBK-LAB, Inc.)
Sunyoung Park (JBK-LAB, Inc.)
Sung-Bae Lee (JBK-LAB, Inc.)
Gun-Woo Lee (JBK-LAB, Inc.)
Young-Sun Kwon (JBK-LAB, Inc.)
Hee-Yeong Jeong (JBK-LAB, Inc.)
Sang-Eun Shin (JBK-LAB, Inc.)
Na Rae Park (JBK-LAB, Inc.)
Bong-Keun Jang (JBK-LAB, Inc.)
- jbk@jbklab.co.kr
Kwang-soon Shin (Kyonggi University)
- ksshin@kyonggi.ac.kr
Abstract
Objective: Chronic alcohol consumption causes neurotoxicity, yet moderate red wine consumption is linked to health benefits, often attributed to its polyphenols. This study investigated whether Nebbiolo red wine (NRW), a variety with high polyphenol content, possesses sufficient neuroprotective capacity to counteract the concurrent neurotoxic effects of its own ethanol (EtOH) content. Materials and Methods: Neuroprotective effects were evaluated in vitro (SH-SY5Y cells, WST-8 assay) and in vivo (mice, Y-maze test) following exposure to 14% EtOH or 14% NRW. Antioxidant capacity was determined by DPPH and ORAC assays. Results: NRW demonstrated robust dose-dependent antioxidant activity. In vitro, NRWP significantly protected SH-SY5Y cells from EtOH-induced cytotoxicity. In vivo, 14% EtOH administration severely impaired spatial memory (27.1% alternation vs. 67.5% Sham), an effect completely prevented by 14% NRW (65% alternation). Conclusion: NRW mediates significant neuroprotection, effectively neutralizing ethanol-induced cytotoxicity in vitro and cognitive impairment in vivo. This suggests polyphenolic content is a critical determinant of alcohol's net neurological impact.
- keywords
- Nebbiolo red wine, Ethanol, Neuroprotection, Oxidative Stress, Cognitive Impairment, Y-maze
- 투고일Received
- 2025-11-24
- 수정일Revised
- 2025-11-27
- 게재확정일Accepted
- 2025-11-28
- 출판일Published
- 2025-11-28
- 다운로드 수
- 조회수
- 0KCI 피인용수
- 0WOS 피인용수