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  • ENGLISH
  • P-ISSN3022-6805
  • E-ISSN3022-6791
  • KCI

ISSN : 3022-6805

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Vol.7 No.3

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Validation of chrysophanol and cordycepin as marker compounds for standardization of a new herbal mixture AST2017-01

셀메드 / CELLMED, (P)3022-6805; (E)3022-6791
2017, v.7 no.3, pp.14-14
장재범 (호서대학교)
김태영 (Gahwa Well Food Co.)
정현자 (호서대학교)
김형민 (경희대학교)
장재범, 김태영, 정현자, & 김형민. (2017). . , 7(3), 14-14.

Abstract

Rumex crispus (RC) or Cordyceps militaris (CM) has been used traditionally to treat various diseases and has been also consumed as a functional food made by humanitas medicine concept. We prepared a new herbal mixture, AST2017-01 which is mainly composed of processed (Beopje)-RC (P-RC) and -CM (P-CM). This study aims to validate marker compounds (chrysophanol and cordycepin) in P-RC and P-CM and water extracted-RC and -CM using liquid chromatography-tandem mass spectrometry. In addition, we analyzed contents of chrysophanol and cordycepin in AST2017-01. The linarites of chrysophanol and cordycepin were obtained in calibration curve with a coefficient of correlation of 0.999. The results showed that the concentrations of chrysophanol and cordycepin in P-RC and P-CM were almost 1.70 and 1.23 fold higher than that in RC and CM, respectively. Furthermore, contents of chrysophanol and cordycepin in the AST2017-01 are approximately 0.13% and 0.028%, respectively. In conclusion, these results indicate that chrysophanol and cordycepin were validated as marker compounds in the AST2017-01.

keywords
Rumex crispus, Cordyceps militaris, liquid chromatography-tandem mass spectrometry, chrysophanol, cordycepin

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