Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation control in dental practice, yet their gastrointestinal risks remain frequently underestimated, particularly in older adults. This report introduces two 80-year-old men with odontogenic infection, who had serious upper gastrointestinal bleeding (UGIB) as a result of abusing NSAIDs before hospitalization. Laboratory test and upper gastrointestinal endoscopy confirmed the UGIB in patients. They received fluid resuscitation and blood transfusion. Hemostasis was achieved through epinephrine injection and cauterization. Patients was kept nir per os, and continuous use of intravenous proton pump inhibitors (PPIs) was followed. These cases highlight the need for appropriate risk assessment and preventive strategies, such as concomitant use of PPIs or use of alternative analgesics, especially in older patients. (J Korean Dent Assoc 2025; 63(12): 406-412)