- KOREAN
- P-ISSN2951-0333
- E-ISSN2951-0597
Two Cases of Semaglutide Use in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease and Autoimmune Hepatitis
Joon Hyuk Choi (Department of Pathology, College of Medicine, Yeungnam University, Daegu, Korea)
Abstract
Concomitant metabolic dysfunction-associated steatotic liver disease (MASLD) and autoimmune hepatitis (AIH) complicates diagnosis, even when liver biopsy is performed. Furthermore, corticosteroid treatment can exacerbate steatosis, often impeding a complete biochemical response. As a result, assessing the histological response remains challenging, even when performing follow-up liver biopsies. Although implementing lifestyle modifications can normalize liver enzyme levels, most patients are unable to achieve adequate weight loss. In contrast, the use of semaglutide facilitated a more effective improvement in liver tests when compared to general lifestyle modifications, thereby enabling clearer assessment of liver function deterioration due to MASLD. Here, we report two cases of a diagnostic trial using semaglutide in patients with MASLD combined with AIH.
- keywords
- Steatohepatitis, Hepatitis, Autoimmune, Metabolic syndrome, Steroids
- Received
- 2025-11-26
- Revised
- 2025-12-16
- Accepted
- 2025-12-17
- Published
- 2025-12-31
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