Abstract

UV spectroscopy methods were created to rapidly and accurately estimate miconazole nitrate in a topical formulation. This technique is simple, specific, linear, accurate, and robust. The environmental impact assessment of the suggested approach was executed by applying the GAPI and AGREE tools. Miconazole nitrate dissolves well in water: Isopropyl alcohol, so a standard stock solution was arranged in water: Isopropyl alcohol. The research employed five miconazole nitrate concentrations, varying from 24 to 72 μg/mL, with the drug showing strong absorbance at 210 nm. The method followed Beer’s law with a 0.999 correlation coefficient and achieved a 99.4 % recovery rate, indicating high accuracy. Inter-day and intra-day precision both had < 2.0 % relative standard deviation. No interference from foreign particles or excipients was observed. Overall, the validated method is specific, reliable, and reproducible for analyzing miconazole nitrate. This cost-effective method is ideal for routine analysis in the pharmaceutical industry due to its simplicity and precision. The method is extremely environmentally friendly and sustainable, making it suitable for regular use in quality control laboratories with minimal environmental impact. In addition, the results of AGREE and GAPI confirmed the environmental friendliness and environmental sustainability of the developed approach.

Graphical Abstract