Determination of Memantine HCl by UV Spectrophotometry using MPCN as an UV-labelling Reagent

Jang, Sun-Sook; 장선숙; Choi, Jung-Kap; 최중갑; Yoo, Gyurng-Soo; 유경수

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P-ISSN1225-0163
E-ISSN2288-8985
SCOPUS, ESCI, KCI

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P-ISSN 1225-0163
E-ISSN 2288-8985

e-Submission

Vol.6, No.4

PubReader Citation

Determination of Memantine HCl by UV Spectrophotometry using MPCN as an UV-labelling Reagent

Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985

1993, v.6 no.4, pp.405-409

Jang, Sun-Sook
Choi, Jung-Kap
Yoo, Gyurng-Soo

Jang, S., Choi, J., & Yoo, G. (1993). Determination of Memantine HCl by UV Spectrophotometry using MPCN as an UV-labelling Reagent. , 6(4), 405-409.

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Abstract

Spectrophotometric assay for memantine HCl was developed by using sodium 1-(4-methoxypheyl) cinnamonitrile-2-sulfonate (MPCN) as an UV labelling reagent. The optimum derivatizing condition was obtained by incubation for 30 min at pH 5.0 in the presence of 20-fold molar excess of the labelling reagent. The absorbance of reaction product was measured at 324.5 nm and detection limit was $0.43{\mu}g/ml$. A linear range was $5.0{\times}10^{-6}{\sim}6.5{\times}10^{-5}M$ of memantine HCl. The linear regression analysis of absorbance at various drug concentration was r