Polycystic Ovarian Syndrome (PCOS) has now become more common in occurrence in women of reproductive age, particularly in urban and semi-urban population in India. So there is a need to investigate this phenomenon taking into consideration various aspects including possible treatment method to ameliorate/eradicate this syndrome, which has far reaching socio-economic impact and consequences, in view of infertility and irregular menstrual cycles frequently associated with this syndrome. Homeopathy is a branch of traditional alternative medicine which is gaining popularity in India and some other developing countries, as also in some of the developed countries in Europe. With this background scenario, we have made an attempt to treat cases of confirmed PCOS and tried to compare the relative efficacy of two potentized homeopathic drugs, namely, Lycopodium clavatum (Lyco) and Calcarea carbonica (Calc), most frequently used by homeopathic practitioners, selecting different potencies of the drugs, depending on condition/guiding symptom(s) of the patients. While the main focus was pointed on total/partial removal of cysts, data pertaining to different PCOS associated symptoms were also compared for the sake of learning if the two drugs had differential effects on these symptoms also. The study parameters in this investigation included: regularity/irregularity of menstrual cycle, presence/absence of acne, hirsutism, male type alopecia, acanthosis nigricans, body/mass index (BMI) and waist-hip ratio. Overall results provided clear evidences that both these homeopathic drugs had great ameliorating effects on PCOS, although each drug had a little different effect in respect of the individual parameters of this study.
Allen HC. Keynotes and characteristics with comparisons of some of the leading remedies of the materia medica with nosodes. 2nd ed. (Noida, India: B. Jain Publishers), 2002.
Asunción M, Calvo RM, San Millán JL, Sancho J, Avila S, Escobar-Morreale HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab. 2000;85:2434-2438.
Bates GW Jr, Propst AM. Polycystic ovarian syndrome management options. Obstet Gynecol Clin North Am. 2012;39:495-506.
Bhuvanashree N, Gupta S, Anitha, M, Venkatarao E. Polycystic ovarian syndrome: Prevalence and its correlates among adolescent girls. Ann Trop Med Public Health. 2013;6:632-636.
Boericke W. Pocket manual of homeopathic material medica &repertory. 9th ed. (Delhi, India: Motilal Banarsidass Publishers), 1993.
Close S. The genius of homoeopathy - Lectures and essays on homeopathic philosophy with word index. 2nd ed. (Noida, India:B. Jain Publishers), 2001.
De Frène V, Verhofstadt L, Lammertyn J, Stuyver I, Buysse A, De Sutter P. Quality of Life and Body Mass Index in Overweight Adult Women with Polycystic Ovary Syndrome During a Lifestyle Modification Program. J Obstet Gynecol Neonatal Nurs. 2015;44:587-599.
Diamanti-Kandarakis E, Kouli C, Tsianateli T, Bergiele A. Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome. Eur J Endocrinol. 1998;138:269-274.
Diamanti-Kandarakis E, Baillargeon JP, Iuorno MJ, Jakubowicz DJ, Nestler JE. A modern medical quandary:polycystic ovary syndrome, insulin resistance, and oral contraceptive pills. J Clin Endocrinol Metab. 2003;88:1927-1932.
Farah L, Lazenby AJ, Boots LR, Azziz R. Prevalence of polycystic ovary syndrome in women seeking treatment from community electrologists. Alabama Professional Electrology Association Study Group. J Reprod Med. 1999;44:870-874.
Farquhar C, Vandekerckhove P, Lilford R. Laparoscopic "drilling" by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome. Cochrane Database Syst Rev. 2001;4:CD001122.
Farquhar C ,Vandekerckhove P, Lilford R , Marjoribanks J, Vanderkerchove P Laparoscopic "drilling" by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome. Cochrane Database Syst Rev. 2007;18:CD001122.
Ganie MA, Marwaha RK, Aggarwal R, Singh S. High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case-control study. Eur J Endocrinol. 2010;162:1117-1122.
Gill H, Tiwari P, Dabadghao P. Prevalence of polycystic ovary syndrome in young women from North India: A Communitybased study. Indian J Endocrinol Metab. 2012;16:S389-S392.
Karn D, K C S, Timalsina M, Gyawali P. Hormonal profile and efficacy of long pulse Nd-YAG laser in treatment of hirsutism. J Nepal Health Res Counc. 2014;12:59-62.
Kent J T. Lectures on Homoeopathic Materia Medica together with Kent’s ‘New Remedies’ in corporated and arranged in alphabetical order. 2nd ed. (Noida, India: B. Jain Publishers), 1982.
Khuda-Bukhsh AR. Towards understanding molecular mechanisms of action of homeopathic drug: An overview. Mol Cell Biochem. 2003;253:339-345.
Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots LR, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab. 1998;83:3078-3782.
Mandal SK, Biswas R, Bhattacharyya SS, Paul S, Dutta S, Pathak S, Khuda-Bukhsh AR. Lycopodine from Licopodium clavatum extract inhibits proliferation on HeLa cells through induction of apoptosis via caspase-3 activation. Eur J Pharmacol. 2010;626:115-122.
McGill DJ, Hutchison C, McKenzie E, McSherry E, Mackay IR. A randomised, split-face comparison of facial hair removal with the alexandrite laser and intense pulsed light system. Lasers Surg Med. 2007;39:767-772.
Witchel SF, Oberfield S, Rosenfield RL, Codner E, Bonny A, Ibáñez L, Pena A, Horikawa R, Gomez-Lobo V, Joel D, Tfayli H, Arslanian S, Dabadghao P, Garcia Rudaz C, Lee PA. The Diagnosis of Polycystic Ovary Syndrome during Adolescence. Horm Res Paediatr. 2015. [Epub ahead of print].