Background: Women undergoing infertility treatment face significant psychological burdens, yet the mechanisms by which psychosocial resources enhance their resilience remain insufficiently understood. Purpose: This study examined the relationships among family support, ego-resiliency, psychological well-being, and resilience in women with infertility, and tested the mediating effect of psychological well-being. Methods: A descriptive correlational design was employed. Data were collected from 210 women with infertility attending fertility clinics at three general hospitals in Seoul and Gyeonggi Province, South Korea, between January and June 2025. Validated instruments were used to measure family support (FSS), ego-resiliency (ERS), psychological well-being (K-PWB), and resilience (RS). Data were analyzed using descriptive statistics, Pearson's correlation coefficients, multiple regression analysis, and Baron and Kenny's mediation analysis. Results: Mean scores were: family support 3.84±0.61, ego-resiliency 3.71±0.58, psychological well-being 3.62±0.67, and resilience 3.78±0.63. Resilience was significantly and positively correlated with family support (r=.61, p<.001), ego-resiliency (r=.68, p<.001), and psychological well-being (r=.72, p<.001). Psychological well-being partially mediated the relationships between both family support and resilience and ego-resiliency and resilience. The total explanatory power for resilience was 63.4%. Conclusion: Family support and ego-resiliency enhance resilience both directly and indirectly through psychological well-being. Nursing interventions targeting all three factors are essential for improving resilience in infertile women.