Purpose: This study aimed to comprehensively examine the effects of expectations regarding aging and SOC (Selection, Optimization, and Compensation) coping strategies on the quality of life among middle-aged women. Research design, data and methodology: An explanatory sequential mixed-methods design was employed. For the quantitative phase, a survey was conducted with 188 middle-aged women aged 40–65, and the data were analyzed using descriptive statistics, correlation analysis, and multiple regression analysis. For the qualitative phase, focus group interviews were conducted with 12 participants and analyzed using Colaizzi’s phenomenological method. Results: Expectations regarding aging and SOC coping strategies showed significant positive correlations with quality of life. The major factors influencing quality of life were SOC coping strategies and expectations regarding aging, with living standard also identified as a significant factor. Qualitative findings revealed differences in perceptions of aging and coping strategies according to living standards; participants with higher living standards demonstrated proactive self-management and positive perceptions of aging, whereas those with lower living standards exhibited economic insecurity and more dependent attitudes. Conclusion: To improve the quality of life of middle-aged women, interventions that strengthen SOC coping strategies and enhance positive expectations regarding aging are needed. Additionally, the development of tailored programs that consider living standards is required.